In 1342, Duke Ludwig took under his protection the Jew Salmen of Innsbruck and his descendants for a yearly payment of 40 Gulden. The anti-Jewish persecutions that followed the plague of 1348-1349 affected the Jews of Innsbruck.
Documentary evidence records that in 1415 Jews were living in Innsbruck again. In 1434 two Jewish taxpayers were mentioned in various documents. From 1451 to 1476 Seligmann, physician of Duke Sigmund, lived in Innsbruck. The expulsion edict of the Jews from Tyrol in 1520 was not enforced in Innsbruck.
In 1598 a Jew living in Innsbruck claimed that “the cemetery below Schloss (Palace) Weyerburg has been used by his ancestors and all the Jews living in Innsbruck for ages”; it is not indicated whether the cemetery dates back to the Middle Ages.